Mlb Opening Day 2025. Traditional opening day, featuring 28 of the 30 major league clubs, will take place on thursday, march 27th. The final day of the 2025 regular season will be sunday, september 28 th, featuring eight divisional matchups.
Shohei ohtani will take the field in his home country to open. The los angeles dodgers and shohei ohtani will open the 2025 season in tokyo against the chicago cubs on march 18 and the athletics will start the home portion of their first.